Table 5

Summary of estrogenic regulation of neuroinflammatory genes.

Symbol

Gene name

RQ(E2)

RQ(LE2)

RQ(DPN)


Analogous changes

C3

complement C3

0.703

0.743

0.801

Ccl2

chemokine (C-C) ligand 2

0.527

0.824

0.703

Fcgr2b

Fc fragment of IgG, receptor

0.615

0.649

0.651

IgG-2a

Ig chain

8.228

9.257

4.048

Il6

interleukin-6

2.823

2.232

2.635

Itgam

CD11b

0.571

0.655

0.798

Np4

defensin NP-4 precursor

2.562

2.268

2.578

RatNP-3b

defensin ratNP-3 precursor

13.266

10.568

4.574

RT1-Aw2

RT1 class Ib

0.606

0.658

0.463

E2-specific changes

C4b

C4

0.670

0.881

0.785

Cx3cr1

fractalkine receptor

0.820

0.914

1.041

Esr1

estrogen receptor-α

1.392

1.169

0.908

Mpeg1

macrophage expressed gene 1

0.611

0.978

0.869

Tgfb1

transforming growth factor beta 1

0.779

0.921

0.938

Tlr4

Toll-like receptor 4

0.810

0.993

1.069

Tlr9

Toll-like receptor 9

0.737

0.896

0.845


The effects of isotype selective ER agonists on the transcription of E2-regulated genes revealed two groups: analogous and specific changes. The large number of analogous changes (genes which are regulated similarly by the three ER agonists) revealed that both ERα and ERβ were involved in the transcriptional regulation of neuroinflammatory genes.

Sárvári et al. Journal of Neuroinflammation 2011 8:82   doi:10.1186/1742-2094-8-82

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