Table 4

The effects of ERα agonist 16α-LE2 and ERβ agonist DPN on the transcription of E2-regulated neuroinflammatory genes.

Symbol

Gene name

TaqMan ID

RQ(LE2)

RQ(DPN)


Complement

C3

complement C3

Rn00566466_m1

0.743

0.801

Defensin

Np4

defensin NP-4 precursor

Rn00597762_g1

2.268

2.578

RatNP-3b

defensin ratNP-3 precursor

Rn01478511_gH

10.568

4.574

Ig chain

IgG-2a

immonoglobulin G

Rn01429839_g1

9.257

4.048

Lymphokine

Ccl2

chemokine (C-C) ligand 2

Rn00580555_m1

0.824

0.703

Il6

interleukin-6

Rn00561420_m1

2.232

2.635

MHC

RT1-Aw2

RT1 class Ib

Rn03034964_u1

0.658

0.463

phagocytic receptor

Fcgr2b

Fc fragment of IgG, receptor

Rn00598391_m1

0.649

0.651

Itgam

CD11b

Rn00709342_m1

0.655

0.798


Nine genes were regulated in a similar way by selective ERα and ERβ agonists indicating that both ERs were involved in the transcriptional regulation of these genes. Relative quantities were the mean of six individual samples. RQ, relative quantity; LE2, 16α-LE2; DPN, diarylpropionitrile.

Sárvári et al. Journal of Neuroinflammation 2011 8:82   doi:10.1186/1742-2094-8-82

Open Data