Figure 5.

Effects on microglial TNF-α (A) and IL-6 (B) secretion into the medium in the presence or absence of Aβ, as well as after pretreatment of Aβ with 10 μg/ml anti-Aβ antibody 6E10. Opsonization with 6E10 significantly enhanced (P < 0.05) (*) TNF-α and IL-6 levels compared to Aβ alone. IL-6 experiments also measured the effect of 1 μg/ml indomethacin on 6E10 exacerbation of cytokine secretion. Indomethacin significantly reduced this effect (P < 0.05) (#).