Additional file 1: Figure S1.
Showing the decline in motor performance during ALS progression correlates with lumbar motor neuron loss in the lumbar spinal cord of hSOD1G93A mice. (A) Significant weight loss of hSOD1G93A mice when compared with wild-type (WT) control mice at 140 days of age (arrow, n = 12, *P <0.05, #P <0.001, Student t test). (B), (C) Significant reduction in time spent on Rota-rod and hind-limb grip strength for hSOD1G93A versus WT mice, at 119 days and 70 days respectively (arrows, n = 12, *P <0.05, +P <0.01, #P <0.001, Student t test). (D) Lumbar motor neuron loss in hSOD1G93A mice when compared with WT control mice at 70 days of age onwards (n = 6, ***P <0.001, Student t test). The decline in motor neuron number at 70 days correlates with the onset of loss of hind limb muscle strength at this same age (C). Data expressed as mean ± standard error of the mean. PS, pre-symptomatic (30 days postnatal (P30)); OS, onset (70 days postnatal (P70)); MS, mid-symptomatic (130 days postnatal (P130)); ES, end-stage (175 days postnatal (P175)).
Format: PDF Size: 435KB Download file
This file can be viewed with: Adobe Acrobat Reader
Lee et al. Journal of Neuroinflammation 2013 10:119 doi:10.1186/1742-2094-10-119