Table 3

Ginkgolides reduce prostaglandin E2 production: Levels of prostaglandin E2 produced by untreated SH-SY5Y cells, or cells pre-treated with 1 μM ginkgolide A, 1 μM ginkgolide B, 25 μM myricetin or 25 μM quercetin and thereafter incubated for 24 hours with 10 μM arachidonic acid, 10 μM amyloid-β1-42 10 μM HuPrP82-146 or 5 μM PAF. Each value is the mean level of prostaglandin E2 (pg/ml) ± SD from triplicate experiments repeated three times (9 observations).

untreated
 HuPrP82-146
 amyloid-β1-42
 arachidonic acid
 PAF
Medium
 <20
 362 ± 46
 323 ± 39
 438 ± 55
 157 ± 38
ginkgolide A
 <20
 66 ± 40**
 57 ± 40**
 234 ± 34**
 45 ± 29**
ginkgolide B
 <20
 <20**
 25 ± 27**
 145 ± 30**
 36 ± 26**
myricetin
 <20
 358 ± 64
 327 ± 36
 450 ± 30
 149 ± 28
quercetin
 <20
 349 ± 51
 319 ± 28
 442 ± 45
 169 ± 29

** = Prostaglandin E2 production significantly less (p < 0.05) than in untreated cells.

Bate et al. Journal of Neuroinflammation 2004 1:4   doi:10.1186/1742-2094-1-4