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1:

GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice.

Li L, Liu J, Suo WZ.

J Neuroinflammation. 2008 Jun 3;5:24.

PMID: 18522748 [PubMed - indexed for MEDLINE]

2:

GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment.

Suo Z, Cox AA, Bartelli N, Rasul I, Festoff BW, Premont RT, Arendash GW.

Neurobiol Aging. 2007 Dec;28(12):1873-88. Epub 2006 Oct 2.

PMID: 17011668 [PubMed - indexed for MEDLINE]

3:

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice.

Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA.

J Neurosci. 2008 Jun 18;28(25):6333-41.

PMID: 18562603 [PubMed - indexed for MEDLINE]

4:

CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase.

Tan J, Town T, Mori T, Wu Y, Saxe M, Crawford F, Mullan M.

J Neurosci. 2000 Oct 15;20(20):7587-94.

PMID: 11027218 [PubMed - indexed for MEDLINE]

5:

Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early beta-amyloid accumulation.

Suo Z, Wu M, Citron BA, Wong GT, Festoff BW.

J Neurosci. 2004 Mar 31;24(13):3444-52.

PMID: 15056724 [PubMed - indexed for MEDLINE]

6:

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.

Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE, Seymour ZM, Guillot F, Gaestel M, Richardson JC.

J Biol Chem. 2006 Aug 18;281(33):23658-67. Epub 2006 Jun 14.

PMID: 16774924 [PubMed - indexed for MEDLINE]

7:

Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice.

Li L, Rasul I, Liu J, Zhao B, Tang R, Premont RT, Suo WZ.

Brain Res Bull. 2008 Oct 24. [Epub ahead of print]

PMID: 18955119 [PubMed - as supplied by publisher]

8:

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

Martini JS, Raake P, Vinge LE, DeGeorge B Jr, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12457-62. Epub 2008 Aug 18.

PMID: 18711143 [PubMed - indexed for MEDLINE]

9:

Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.

Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ.

Circ Res. 2000 Jan 7-21;86(1):43-50.

PMID: 10625304 [PubMed - indexed for MEDLINE]

10:

G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.

Walker JK, Gainetdinov RR, Feldman DS, McFawn PK, Caron MG, Lefkowitz RJ, Premont RT, Fisher JT.

Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L312-9. Epub 2003 Oct 17.

PMID: 14565944 [PubMed - indexed for MEDLINE]

11:

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN.

J Neurosci. 2002 Mar 15;22(6):2246-54.

PMID: 11896164 [PubMed - indexed for MEDLINE]

12:

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K.

Am J Pathol. 2001 Apr;158(4):1345-54.

PMID: 11290552 [PubMed - indexed for MEDLINE]

13:

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice.

Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, Koistinaho J.

Neurobiol Dis. 2005 Feb;18(1):134-42.

PMID: 15649704 [PubMed - indexed for MEDLINE]

14:

Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice.

Xu F, Vitek MP, Colton CA, Previti ML, Gharkholonarehe N, Davis J, Van Nostrand WE.

J Neurosci. 2008 May 14;28(20):5312-20.

PMID: 18480287 [PubMed - indexed for MEDLINE]

15:

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.

Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW.

J Neuroinflammation. 2008 Apr 9;5:13.

PMID: 18400101 [PubMed - indexed for MEDLINE]

16:

Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.

Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D.

J Neurosci. 2003 May 1;23(9):3745-51.

PMID: 12736345 [PubMed - indexed for MEDLINE]

17:

CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide.

Townsend KP, Town T, Mori T, Lue LF, Shytle D, Sanberg PR, Morgan D, Fernandez F, Flavell RA, Tan J.

Eur J Immunol. 2005 Mar;35(3):901-10.

PMID: 15688347 [PubMed - indexed for MEDLINE]

18:

Microglial response to amyloid plaques in APPsw transgenic mice.

Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM.

Am J Pathol. 1998 Jan;152(1):307-17.

PMID: 9422548 [PubMed - indexed for MEDLINE]

19:

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G.

J Neurosci. 2003 Aug 20;23(20):7504-9.

PMID: 12930788 [PubMed - indexed for MEDLINE]

20:

Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology.

Leal MC, Dorfman VB, Gamba AF, Frangione B, Wisniewski T, Castaño EM, Sigurdsson EM, Morelli L.

J Neuropathol Exp Neurol. 2006 Oct;65(10):976-87.

PMID: 17021402 [PubMed - indexed for MEDLINE]

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