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The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.

Tran TA, McCoy MK, Sporn MB, Tansey MG.

J Neuroinflammation. 2008 May 12;5:14.

PMID: 18474101 [PubMed - indexed for MEDLINE]

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3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity.

Zhang W, Qin L, Wang T, Wei SJ, Gao HM, Liu J, Wilson B, Liu B, Zhang W, Kim HC, Hong JS.

FASEB J. 2005 Mar;19(3):395-7. Epub 2004 Dec 13.

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Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity.

Zhang D, Hu X, Wei SJ, Liu J, Gao H, Qian L, Wilson B, Liu G, Hong JS.

J Neuroinflammation. 2008 May 28;5:21.

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Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.

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Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response.

Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG.

J Neurosci. 2008 Aug 20;28(34):8517-28.

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Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.

Qian L, Xu Z, Zhang W, Wilson B, Hong JS, Flood PM.

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Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

Liu Y, Qin L, Li G, Zhang W, An L, Liu B, Hong JS.

J Pharmacol Exp Ther. 2003 Apr;305(1):212-8.

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Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).

Yue P, Zhou Z, Khuri FR, Sun SY.

Cancer Biol Ther. 2006 May;5(5):492-7. Epub 2006 May 2.

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Vitamin E suppression of microglial activation is neuroprotective.

Li Y, Liu L, Barger SW, Mrak RE, Griffin WS.

J Neurosci Res. 2001 Oct 15;66(2):163-70.

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10:

c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY.

Cancer Res. 2004 Oct 15;64(20):7570-8.

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11:

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.

Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB.

Clin Cancer Res. 2006 Mar 15;12(6):1828-38.

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12:

Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons.

Li FQ, Wang T, Pei Z, Liu B, Hong JS.

J Neural Transm. 2005 Mar;112(3):331-47. Epub 2004 Oct 22.

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13:

Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.

Peng GS, Li G, Tzeng NS, Chen PS, Chuang DM, Hsu YD, Yang S, Hong JS.

Brain Res Mol Brain Res. 2005 Mar 24;134(1):162-9. Epub 2004 Nov 25.

PMID: 15790540 [PubMed - indexed for MEDLINE]

14:

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

Ralay Ranaivo H, Craft JM, Hu W, Guo L, Wing LK, Van Eldik LJ, Watterson DM.

J Neurosci. 2006 Jan 11;26(2):662-70.

PMID: 16407564 [PubMed - indexed for MEDLINE]

15:

Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration.

Wang X, Chen S, Ma G, Ye M, Lu G.

Mech Ageing Dev. 2005 Dec;126(12):1241-54. Epub 2005 Aug 19.

PMID: 16112714 [PubMed - indexed for MEDLINE]

16:

c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.

Zou W, Chen S, Liu X, Yue P, Sporn MB, Khuri FR, Sun SY.

Cancer Biol Ther. 2007 Oct;6(10):1614-20. Epub 2007 Jul 19.

PMID: 18253090 [PubMed - indexed for MEDLINE]

17:

Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.

Kim KB, Lotan R, Yue P, Sporn MB, Suh N, Gribble GW, Honda T, Wu GS, Hong WK, Sun SY.

Mol Cancer Ther. 2002 Jan;1(3):177-84.

PMID: 12467212 [PubMed - indexed for MEDLINE]

18:

Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

Qin L, Liu Y, Cooper C, Liu B, Wilson B, Hong JS.

J Neurochem. 2002 Nov;83(4):973-83.

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19:

The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.

Stadheim TA, Suh N, Ganju N, Sporn MB, Eastman A.

J Biol Chem. 2002 May 10;277(19):16448-55. Epub 2002 Mar 5.

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20:

Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures.

Tian YY, An LJ, Jiang L, Duan YL, Chen J, Jiang B.

Life Sci. 2006 Dec 23;80(3):193-9. Epub 2006 Sep 20.

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