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Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.

Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW.

J Neuroinflammation. 2008 Apr 9;5:13.

PMID: 18400101 [PubMed - indexed for MEDLINE]

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CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide.

Townsend KP, Town T, Mori T, Lue LF, Shytle D, Sanberg PR, Morgan D, Fernandez F, Flavell RA, Tan J.

Eur J Immunol. 2005 Mar;35(3):901-10.

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Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology.

Mehlhorn G, Hollborn M, Schliebs R.

Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):423-31.

PMID: 10817926 [PubMed - indexed for MEDLINE]

Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse.

Nichol KE, Parachikova AI, Cotman CW.

Behav Brain Res. 2007 Dec 3;184(2):124-32. Epub 2007 Jul 10.

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Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease.

Jin JJ, Kim HD, Maxwell JA, Li L, Fukuchi K.

J Neuroinflammation. 2008 May 29;5:23.

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Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.

Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T.

Am J Pathol. 2007 Feb;170(2):680-92.

PMID: 17255335 [PubMed - indexed for MEDLINE]

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Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease.

Sly LM, Krzesicki RF, Brashler JR, Buhl AE, McKinley DD, Carter DB, Chin JE.

Brain Res Bull. 2001 Dec;56(6):581-8.

PMID: 11786245 [PubMed - indexed for MEDLINE]

Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology.

Münch G, Apelt J, Rosemarie-Kientsch-Engel, Stahl P, Lüth HJ, Schliebs R.

J Neurochem. 2003 Jul;86(2):283-9.

PMID: 12871569 [PubMed - indexed for MEDLINE]

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition.

Parachikova A, Nichol KE, Cotman CW.

Neurobiol Dis. 2008 Apr;30(1):121-9. Epub 2008 Jan 5.

PMID: 18258444 [PubMed - indexed for MEDLINE]

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CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.

Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J.

Neurobiol Dis. 2008 Feb;29(2):336-53. Epub 2007 Oct 16.

PMID: 18055209 [PubMed - indexed for MEDLINE]

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Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice.

Nikolic WV, Hou H, Town T, Zhu Y, Giunta B, Sanberg CD, Zeng J, Luo D, Ehrhart J, Mori T, Sanberg PR, Tan J.

Stem Cells Dev. 2008 Jun;17(3):423-39.

PMID: 18366296 [PubMed - indexed for MEDLINE]

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Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.

Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA.

Nat Med. 2008 Jun;14(6):681-7. Epub 2008 Jun 1.

PMID: 18516051 [PubMed - indexed for MEDLINE]

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Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease.

Monsonego A, Imitola J, Petrovic S, Zota V, Nemirovsky A, Baron R, Fisher Y, Owens T, Weiner HL.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5048-53. Epub 2006 Mar 20.

PMID: 16549802 [PubMed - indexed for MEDLINE]

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Ginger extract inhibits beta-amyloid peptide-induced cytokine and chemokine expression in cultured THP-1 monocytes.

Grzanna R, Phan P, Polotsky A, Lindmark L, Frondoza CG.

J Altern Complement Med. 2004 Dec;10(6):1009-13.

PMID: 15673995 [PubMed - indexed for MEDLINE]

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MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.

Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE, Seymour ZM, Guillot F, Gaestel M, Richardson JC.

J Biol Chem. 2006 Aug 18;281(33):23658-67. Epub 2006 Jun 14.

PMID: 16774924 [PubMed - indexed for MEDLINE]

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Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576.

Tehranian R, Hasanvan H, Iverfeldt K, Post C, Schultzberg M.

Neurosci Lett. 2001 Mar 23;301(1):54-8.

PMID: 11239715 [PubMed - indexed for MEDLINE]

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG.

J Neurosci. 2001 Jan 15;21(2):372-81.

PMID: 11160418 [PubMed - indexed for MEDLINE]

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Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40.

Suo Z, Tan J, Placzek A, Crawford F, Fang C, Mullan M.

Brain Res. 1998 Oct 5;807(1-2):110-7.

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Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice.

Abbas N, Bednar I, Mix E, Marie S, Paterson D, Ljungberg A, Morris C, Winblad B, Nordberg A, Zhu J.

J Neuroimmunol. 2002 May;126(1-2):50-7.

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Intracerebroventricular passive immunization with anti-Abeta antibody in Tg2576.

Chauhan NB, Siegel GJ.

J Neurosci Res. 2003 Oct 1;74(1):142-7.

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