Open Access Highly Accessed Open Badges Research

Association of the interleukin 1 beta gene and brain spontaneous activity in amnestic mild cognitive impairment

Liying Zhuang12, Xiaoyan Liu12, Xiaohui Xu12, Chunxian Yue12, Hao Shu12, Feng Bai12, Hui Yu1, Yongmei Shi12 and Zhijun Zhang12*

Author Affiliations

1 Medical School of Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China

2 Department of Neurology, Affiliated Zhongda Hospital of Southeast University, and the Institute of Neuropsychiatry of Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China

For all author emails, please log on.

Journal of Neuroinflammation 2012, 9:263  doi:10.1186/1742-2094-9-263

Published: 1 December 2012



The inflammatory response has been associated with the pathogenesis of Alzheimer’s disease (AD). The purpose of this study is to determine whether the rs1143627 polymorphism of the interleukin-1 beta (IL-1β) gene moderates functional magnetic resonance imaging (fMRI)-measured brain regional activity in amnestic mild cognitive impairment (aMCI).


Eighty older participants (47 with aMCI and 33 healthy controls) were recruited for this study. All of the participants were genotyped for variant rs1143627 in the IL1B gene and were scanned using resting-state fMRI. Brain activity was assessed by amplitude of low-frequency fluctuation (ALFF).


aMCI patients had abnormal ALFF in many brain regions, including decreases in the inferior frontal gyrus, the superior temporal lobe and the middle temporal lobe, and increases in the occipital cortex (calcarine), parietal cortex (Pcu) and cerebellar cortex. The regions associated with an interaction of group X genotypes of rs1143627 C/T were the parietal cortex (left Pcu), frontal cortex (left superior, middle, and medial gyrus, right anterior cingulum), occipital cortex (left middle lobe, left cuneus) and the bilateral posterior lobes of the cerebellum. Regarding the behavioral significance, there were significant correlations between ALFF in different regions of the brain and with the cognitive scores of each genotype group.


The present study provided evidence that aMCI patients had abnormal ALFF in many brain regions. Specifically, the rs1143627 C/T polymorphism of the IL1B gene may modulate regional spontaneous brain activity in aMCI patients.

Amnestic mild cognitive impairment; Functional magnetic resonance imaging; Amplitude of low-frequency fluctuation; Interleukin-1 beta; Cognition