Table 3

Real-time PCR revealed that E2 regulated the transcription of neuroinflammatory genes in the frontal cortex of middle-aged female rats.

Symbol

Gene name

TaqMan ID

RQ(E2)

p


complement

C3

complement C3

Rn00566466_m1

0.70

0.02

C4b

complement C4

Rn00709527_m1

0.67

0.07

defensin

Np4

defensin NP-4 precursor

Rn00597762_g1

2.56

0.08

RatNP-3b

defensin ratNP-3 precursor

Rn01478511_gH

13.27

0.06

Ig chain

IgG-2a

immonoglobulin G

Rn01429839_g1

8.23

0.10

lymphokine

Ccl2

chemokine (C-C) ligand 2

Rn00580555_m1

0.52

0.06

Il6

interleukin-6

Rn00561420_m1

2.82

0.04

Tgfb1

transforming growth factor beta 1

Rn00572010_m1

0.78

0.01

MHC

RT1-Aw2

RT1 class Ib

Rn03034964_u1

0.61

0.10

miscellaneous

Cx3cr1

fractalkine receptor

Rn00591798_m1

0.82

0.04

Mpeg1

macrophage expressed gene 1

Rn02769865_s1

0.61

0.01

nuclear receptor

Esr1

estrogen receptor-α

Rn00562166_m1

1.39

0.05

phagocytic receptor

Fcgr2b

Fc fragment of IgG, receptor

Rn00598391_m1

0.61

0.03

Itgam

CD11b

Rn00709342_m1

0.57

0.01

Toll-like receptor

Tlr4

Toll-like receptor 4

Rn00569848_m1

0.81

0.05

Tlr9

Toll-like receptor 9

Rn01640054_m1

0.74

0.07


Relative quantities were the mean of six individual samples. One-way ANOVA was used to evaluate statistical significance. RQ, relative quantity.

Sárvári et al. Journal of Neuroinflammation 2011 8:82   doi:10.1186/1742-2094-8-82

Open Data