Aβ-related NK cell induced changes are attenuated by Atorvastatin. A, Expression of CD161 and B, NKp46 assessed by western immunoblotting. Densititometry data is expressed in arbitrary units relative to β-Actin C, IFNγ concentration, D, CD11b mRNA, E, MHCII mRNA, F, MCP-1 mRNA and G, IP-10 mRNA (*p < 0.05; **p < 0.01; ***p < 0.001; ANOVA; n = 6-7) were significantly increased in hippocampal tissue prepared from rats which received an intracerebroventricular injection of Aβ1-42 (5 μl; 200 μM) or vehicle. These changes were attenuated in hippocampal tissue prepared Aβ-treated rats which received atorvastatin (ATV; 5 mg/kg per day) for 3 weeks (ATV; #p < 0.05; ###p < 0.001; vs Aβ-treated rats which did not receive atorvastatin; ANOVA).
Lyons et al. Journal of Neuroinflammation 2011 8:27 doi:10.1186/1742-2094-8-27