Table 1

Secretory/Expression Products of Endothelial Cells*

Extracellular matrix factors

Proteases


fibronectin

Thrombin


laminin

MMPs


collagen I, II, III, IV, VIII, XVIII

tPA


proteoglycans

Growth factors


Anti- and pro- coagulation factors

PDGF


PGI2

EDGF


thrombomodulin

FGF


AT III

IGF


heparin sulfate

TGF-β


vWF

GM-CSF


TXA2

G-CSF


thromboplastin

Vasorelaxation factors


Factor V

NO


PAF

PGI2/E2


PAI-1, PAI-2

EDHF


Inflammatory Chemokines and Cytokines

Vasoconstriction factors


IL-1, IL-6, IL-8

TXA2/F2a


LTB4, C4, D4, E4

EDCF


MCP-1, MCP-2

leukotrienes


MHC II

free radicals


CAM

endothelin


*See text for references

Abbreviations used: prostacyclin (PGI2), anti-thrombin III (AT III), von Willebrand factor (vWF), thromboxane A2 (TXA2), platelet-activating factor (PAF), plasminogen activator inhibitor-1 (PAI-1), plasminogen activator inhibitor-2 (PAI-2), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), leukotriene B4 (LTB4), leukotriene C4 (LTC4), leukotriene D4 (LTD4), leukotriene E4 (LTE4), monocyte chemoattractant protein-1 (MCP-1), monocyte chemoattractant protein-2 (MCP-2), major histocompatibility complex class II (MHC II), cell adhesion molecules (CAM), matrix metalloproteinases (MMPs), tissue plasminogen activator (tPA), platelet-derived growth factor (PDGF), endothelium derived growth factor (EDGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), transforming growth factor beta (TGF-β), granulocyte macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), nitric oxide (NO), prostacyclin/prostaglandin E2 (PGI2/E2), endothelium derived hyperpolarizing factor (EDHF), thromboxane A2/prostaglandin F2a (TXA2/F2a), endothelium derived contracting factor (EDCF)

Grammas Journal of Neuroinflammation 2011 8:26   doi:10.1186/1742-2094-8-26

Open Data