Email updates

Keep up to date with the latest news and content from JNI and BioMed Central.

Open Access Research

Differential contribution of electrically evoked dorsal root reflexes to peripheral vasodilatation and plasma extravasation

Oleg V Lobanov and Yuan B Peng*

Author Affiliations

Department of Psychology, University of Texas at Arlington, Arlington, TX 76019, USA

For all author emails, please log on.

Journal of Neuroinflammation 2011, 8:20  doi:10.1186/1742-2094-8-20

Published: 28 February 2011

Abstract

Background

Dorsal root reflexes (DRRs) are antidromic activities traveling along the primary afferent fibers, which can be generated by peripheral stimulation or central stimulation. DRRs are thought to be involved in the generation of neurogenic inflammation, as indicated by plasma extravasation and vasodilatation. The hypothesis of this study was that electrical stimulation of the central stump of a cut dorsal root would lead to generation of DRRs, resulting in plasma extravasation and vasodilatation.

Methods

Sprague-Dawley rats were prepared to expose spinal cord and L4-L6 dorsal roots under pentobarbital general anesthesia. Electrical stimulation of either intact, proximal or distal, cut dorsal roots was applied while plasma extravasation or blood perfusion of the hindpaw was recorded.

Results

While stimulation of the peripheral stump of a dorsal root elicited plasma extravasation, electrical stimulation of the central stump of a cut dorsal root generated significant DRRs, but failed to induce plasma extravasation. However, stimulation of the central stump induced a significant increase in blood perfusion.

Conclusions

It is suggested that DRRs are involved in vasodilatation but not plasma extravasation in neurogenic inflammation in normal animals.