Table 5 |
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|
Gene expression levels of age and cognitive status groups, presented as group mean (% of adult mean) ± SEM |
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|
CA1 |
CA3 |
DG |
synaptosomes (whole-hippocampus) |
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|
|
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|
Aged |
Aged |
Aged |
Aged |
Aged |
Aged |
Aged |
Aged |
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|
|
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|
Gene |
Adult |
Aged |
Intact |
Impaired |
Adult |
Aged |
Intact |
Impaired |
Adult |
Aged |
Intact |
Impaired |
Adult |
Aged |
Intact |
Impaired |
|
|
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|
C1s |
100 ± 2.8 |
121 ± 6.1 |
125 ± 11.7 |
118 ± 6.6 |
100 ± 7.8 |
156 ± 7.6 |
159 ± 13.4 |
153 ± 9.3 |
100 ± 6.1 |
122 ± 4.8 |
117 ± 5.7 |
125 ± 6.9 |
100 ± 21.7 |
184 ± 21.8 |
182 ± 28.6 |
186 ± 35.3 |
|
|
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|
C3 |
100 ± 6.6 |
200 ± 10.9 |
207 ± 16.4 |
194 ± 15.0 |
100 ± 7.9 |
196 ± 10.8 |
222 ± 17.8 |
178 ± 10.7 |
100 ± 8.1 |
169 ± 7.2 |
152 ± 10.2 |
181 ± 8.3 |
100 ± 23.2 |
347 ± 35.7 |
340 ± 27.6 |
355 ± 74.4 |
|
|
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|
Serping1 |
100 ± 7.4 |
203 ± 13.4 |
218 ± 14.6 |
192 ± 20.2 |
100 ± 7.3 |
227 ± 11.5 |
252 ± 17.4 |
209 ± 13.1 |
100 ± 4.8 |
154 ± 6.3 |
149 ± 9.4 |
158 ± 8.7 |
100 ± 6.9 |
271 ± 12.4 |
279 ± 19.9 |
263 ± 15.5 |
|
|
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|
Cd74 |
100 ± 7.7 |
561 ± 33.3 |
566 ± 44.5 |
558 ± 47.9 |
100 ± 10.9 |
361 ± 20.5 |
388 ± 37.6 |
340 ± 21.2 |
100 ± 7.7 |
243 ± 17.2 |
233 ± 36.7 |
249 ± 18.2 |
100 ± 28.8 |
658 ± 48.9 |
679 ± 46.7 |
635 ± 95.8 |
|
|
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|
C4a |
100 ± 7.1 |
177 ± 7.0 |
167 ± 11.1 |
185 ± 8.6 |
100 ± 4.8 |
151 ± 4.6 |
158 ± 6.2 |
147 ± 6.2 |
100 ± 9.7 |
135 ± 10.3 |
117 ± 15.2 |
147 ± 13.0 |
100 ± 17.7 |
418 ± 44.6 |
383 ± 31.6 |
459 ± 88.3 |
|
|
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|
Ccr5 |
100 ± 5.2 |
108 ± 5.1 |
106 ± 5.2 |
110 ± 7.8 |
100 ± 3.1 |
121 ± 6.3 |
117 ± 7.3 |
125 ± 10.3 |
100 ± 6.9 |
99 ± 7.0 |
88 ± 7.1 |
106 ± 10.4 |
100 ± 17.9 |
196 ± 23.0 |
172 ± 18.8 |
220 ± 41.8 |
|
|
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|
Cp |
100 ± 5.4 |
93 ± 8.2 |
93 ± 6.9 |
93 ± 13.5 |
100 ± 3.9 |
156 ± 6.3 |
164 ± 9.2 |
150 ± 8.4 |
100 ± 9.2 |
110 ± 8.0 |
118 ± 13.7 |
103 ± 9.8 |
100 ± 10.8 |
167 ± 17.1 |
192 ± 28.6 |
146 ± 18.4 |
|
|
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|
Ctse |
100 ± 8.0 |
145 ± 10.2 |
141 ± 13.7 |
148 ± 14.4 |
100 ± 9.8 |
175 ± 7.4 |
173 ± 13.9 |
177 ± 8.7 |
100 ± 6.8 |
148 ± 6.8 |
140 ± 11.3 |
154 ± 8.4 |
100 ± 21.0 |
169 ± 12.0 |
181 ± 19.8 |
156 ± 11.4 |
|
|
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|
Erbb3 |
100 ± 2.7 |
134 ± 5.1 |
143 ± 7.5 |
128 ± 6.5 |
100 ± 8.1 |
120 ± 5.1 |
128 ± 9.1 |
114 ± 5.6 |
100 ± 7.5 |
140 ± 7.8 |
129 ± 10.9 |
147 ± 10.3 |
100 ± 5.4 |
128 ± 4.0 |
126 ± 6.5 |
130 ± 4.6 |
|
|
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|
Fcgr2b |
100 ± 3.2 |
108 ± 7.9 |
103 ± 6.4 |
112 ± 13.0 |
100 ± 9.0 |
161 ± 5.2 |
163 ± 12.0 |
160 ± 3.6 |
100 ± 4.2 |
124 ± 11.0 |
125 ± 19.8 |
123 ± 13.2 |
100 ± 20.8 |
196 ± 15.4 |
208 ± 22.6 |
182 ± 21.2 |
|
|
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|
Fcgr2a |
100 ± 4.4 |
119 ± 4.8 |
116 ± 3.8 |
120 ± 7.7 |
100 ± 5.2 |
130 ± 4.2 |
130 ± 6.4 |
130 ± 5.9 |
100 ± 5.1 |
115 ± 3.8 |
109 ± 5.0 |
120 ± 5.0 |
100 ± 15.2 |
145 ± 11.4 |
143 ± 10.7 |
147 ± 22.8 |
|
|
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|
Hla-dmb |
100 ± 4.6 |
137 ± 4.6 |
133 ± 5.2 |
140 ± 7.3 |
100 ± 3.9 |
137 ± 3.7 |
139 ± 5.9 |
135 ± 4.9 |
100 ± 7.4 |
126 ± 4.4 |
115 ± 6.6 |
133 ± 4.7 |
100 ± 3.3 |
164 ± 8.3 |
157 ± 13.7 |
172 ± 8.4 |
|
|
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|
Hla-dra |
100 ± 7.9 |
404 ± 19.0 |
418 ± 28.1 |
395 ± 26.5 |
100 ± 14.7 |
302 ± 23.4 |
325 ± 47.0 |
285 ± 23.4 |
100 ± 9.7 |
181 ± 22.4 |
190 ± 43.4 |
175 ± 26.4 |
100 ± 24.0 |
630 ± 51.8 |
676 ± 67.9 |
575 ± 79.8 |
|
|
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|
Hsbp1 |
100 ± 12.8 |
168 ± 9.6 |
165 ± 14.0 |
170 ± 13.6 |
100 ± 8.7 |
209 ± 11.0 |
225 ± 18.7 |
197 ± 13.0 |
100 ± 9.5 |
109 ± 11.5 |
80 ± 14.2 |
130 ± 13.8 |
100 ± 17.7 |
287 ± 25.1 |
313 ± 30.1 |
258 ± 40.9 |
|
|
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|
Icam1 |
100 ± 5.5 |
155 ± 7.6 |
168 ± 11.9 |
146 ± 9.4 |
100 ± 5.6 |
143 ± 4.2 |
164 ± 13.3 |
131 ± 5.7 |
100 ± 12.2 |
102 ± 6.5 |
100 ± 13.5 |
102 ± 6.5 |
100 ± 11.1 |
146 ± 11.8 |
145 ± 16.7 |
147 ± 18.3 |
|
|
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|
Lgals3 |
100 ± 4.9 |
264 ± 16.6 |
262 ± 21.4 |
266 ± 24.9 |
100 ± 7.3 |
198 ± 12.6 |
218 ± 16.3 |
184 ± 17.4 |
100 ± 10.5 |
184 ± 12.9 |
163 ± 10.0 |
200 ± 20.2 |
100 ± 21.4 |
342 ± 34.1 |
368 ± 54.6 |
303 ± 39.2 |
|
|
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|
Hla-drb1 |
100 ± 11.0 |
713 ± 57.0 |
712 ± 96.9 |
713 ± 73.8 |
100 ± 9.7 |
439 ± 34.8 |
477 ± 73.9 |
412 ± 30.1 |
100 ± 14.1 |
291 ± 40.2 |
225 ± 44.4 |
342 ± 59.0 |
100 ± 7.6 |
1050 ± 67.3 |
1070 ± 97.4 |
1026 ± 100.2 |
|
|
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|
S100a6 |
100 ± 2.8 |
203 ± 11.5 |
200 ± 16.2 |
206 ± 16.9 |
100 ± 7.5 |
221 ± 13.4 |
248 ± 20.9 |
202 ± 15.5 |
100 ± 16.3 |
110 ± 8.3 |
88 ± 15.5 |
123 ± 7.4 |
100 ± 9.0 |
152 ± 13.1 |
161 ± 24.3 |
145 ± 15.5 |
|
|
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|
Tlr2 |
100 ± 6.3 |
106 ± 5.7 |
109 ± 9.8 |
104 ± 7.2 |
100 ± 11.2 |
154 ± 9.6 |
166 ± 18.9 |
146 ± 9.7 |
100 ± 16.6 |
172 ± 18.8 |
166 ± 36.7 |
176 ± 22.7 |
100 ± 13.0 |
164 ± 11.3 |
155 ± 19.2 |
173 ± 12.9 |
|
|
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|
Tlr4 |
100 ± 2.7 |
135 ± 8.1 |
118 ± 12.8 |
143 ± 9.7 |
100 ± 8.4 |
196 ± 9.5 |
200 ± 19.7 |
193 ± 9.6 |
100 ± 8.7 |
119 ± 4.0 |
118 ± 5.9 |
120 ± 5.7 |
100 ± 8.3 |
151 ± 10.1 |
141 ± 4.9 |
160 ± 19.7 |
|
|
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|
Tlr7 |
100 ± 3.5 |
134 ± 6.5 |
134 ± 17.2 |
135 ± 3.9 |
100 ± 8.1 |
173 ± 5.0 |
174 ± 9.6 |
172 ± 5.7 |
100 ± 11.6 |
94 ± 7.6 |
95 ± 11.6 |
93 ± 10.7 |
100 ± 13.3 |
169 ± 11.3 |
165 ± 16.6 |
173 ± 16.5 |
|
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|
VanGuilder et al. Journal of Neuroinflammation 2011 8:138 doi:10.1186/1742-2094-8-138 |
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