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Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

Daniel Paris*, Nowell J Ganey, Vincent Laporte, Nikunj S Patel, David Beaulieu-Abdelahad, Corbin Bachmeier, Amelia March, Ghania Ait-Ghezala and Michael J Mullan

Journal of Neuroinflammation 2010, 7:17  doi:10.1186/1742-2094-7-17

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Celastrol is not an epoxide

Daniel Paris   (2013-03-21 16:24)  Roskamp Institute

Celastrol is present in a vine which is widely distributed in eastern and southern China (Tripterygium wilfordii) which is also known in the Chinese language as "Lei Gong Teng" (Thunder God Vine) and has a long history of therapeutic use in traditional Chinese medicine [The Editorial Board of Chinese Materia Medica of State Administration of Traditional Chinese medicine of P. R. China. Chinese Materia Medica; Shanghai Scientific and Technical Publishers: Shanghai, China, 1999; Volume 5, pp. 206:215]. Triptolide and celastrol are known active ingredients of Tripterygium wilfordii. We wrongfully referred celastrol as being an epoxide in the results section of our manuscript. Celastrol is a pentacyclic triterpenoid whereas triptolide is a diterpenoid epoxide.

Competing interests

No competing interest.

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