Table 3 |
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|
Peak CSF and corresponding serum values (pg/ml) of immune mediators in animals that were inoculated with B. burgdorferi. |
|||||
| MEDIATOR |
DR50 |
EL81 |
EP51 |
DH50 |
CH82 |
|
|
|||||
| IL-6 |
(wk-1) |
(wk-1) |
(wk-1) |
(wk-1) |
(wk-1) |
| CSF |
17.8 ± 0.4 |
10 ± 0.9 |
3.7 ± 0.5 |
46.9 ± 0.2 |
2.9 ± 0.7 |
| SERUM |
0.7 ± 0.2 |
0.3 ± 0.05 |
1 ± 0.2 |
0 |
3.9 ± 0.5 |
|
|
|||||
| IL-8 |
(wk-1) |
(wk-2) |
(wk-2) |
(wk-1) |
(wk-2) |
| CSF |
33.4 ± 4.2 |
15.7 ± 0.1 |
21.9 ± 1.0 |
34.5 ± 0.9 |
10.9 ± 2.0 |
| SERUM |
832.8 ± 75 |
697.6 ± 86.2 |
625.6 ± 3.7 |
3442 ± 149.2 |
422.4 ± 25 |
|
|
|||||
| CCL2/MCP-1 |
(wk-2) |
(wk 2) |
(wk-3) |
(wk-3) |
|
| CSF |
475.9 ± 25.2 |
345.6 ± 62.3 |
404.5 ± 6.8 |
442.3 ± 6.8 |
* |
| SERUM |
114.1 ± 6.5 |
71.8 ± 0.4 |
106.2 ± 2.8 |
39 ± 11.2 |
|
|
|
|||||
| CXCL13/BLC |
(wk-3) |
(wk-2) |
(wk-4) |
(wk-3) |
|
| CSF |
5500 |
811.5 |
779 |
5317.8 ± 70.5 |
* |
| SERUM |
300 |
748 |
1221 |
199 |
|
|
The time points at which peak values of various immune mediators (pg/ml) were observed in the CSF and corresponding values found in the serum of B. burgdorferi-infected animals are shown. Data represent the mean ± SD of duplicate determinations, except for CXCL13 in animals DR50, EL81, and EP51, where remaining CSF volume available only permitted a single determination. * CSF concentrations of CCL2 and CXCL13 for animal CH82 were not significantly elevated with respect to control animals. | |||||
Ramesh et al. Journal of Neuroinflammation 2009 6:23 doi:10.1186/1742-2094-6-23 |
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