Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Onofre Combarros¹ , Cornelia M van Duijn² , Naomi Hammond³ , Olivia Belbin⁴ , Alejandro Arias-Vásquez² , Mario Cortina-Borja⁵ , Michael G Lehmann⁶ , Yurii S Aulchenko² , Maaike Schuur^2,7 , Heike Kölsch⁸ , Reinhard Heun^8,9 , Gordon K Wilcock^10,11 , Kristelle Brown⁴ , Patrick G Kehoe¹¹ , Rachel Harrison¹¹ , Eliecer Coto¹² , Victoria Alvarez¹² , Panos Deloukas³ , Ignacio Mateo¹ , Rhian Gwilliam³ , Kevin Morgan⁴ , Donald R Warden⁶ , A David Smith⁶ and Donald J Lehmann⁶

¹  Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Marqués de Valdecilla University Hospital (University of Cantabria), 39008 Santander, Spain

²  Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

³  The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK

⁴  School of Molecular Medical Sciences, Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK

⁵  Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK

⁶  Oxford Project to Investigate Memory and Ageing (OPTIMA), University Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK

⁷  Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

⁸  Department of Psychiatry, University of Bonn, Bonn, Germany

⁹  Department of Psychiatry, Derby City General Hospital, Uttoxeter Road, Derby DE22 3NE, UK

¹⁰  Nuffield Department of Medicine, University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK

¹¹  Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Frenchay Hospital, Frenchay, Bristol BS32 8BE, UK

¹²  Genética Molecular, Hospital Central de Asturias, Oviedo, Spain