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Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

Gretchen Hermes1,2 email, James W Ajioka3 email, Krystyna A Kelly3 email, Ernest Mui1 email, Fiona Roberts4 email, Kristen Kasza5 email, Thomas Mayr3 email, Michael J Kirisits1,2 email, Robert Wollmann6 email, David JP Ferguson7 email, Craig W Roberts8 email, Jong-Hee Hwang9 email, Toria Trendler1,2 email, Richard P Kennan9 email, Yasuhiro Suzuki10 email, Catherine Reardon3 email, William F Hickey11 email, Lieping Chen12 email and Rima McLeod1,2,13 email

Department of Ophthalmology, University of Chicago, Chicago, IL, USA

Committee on Immunology, University of Chicago, Chicago, IL, USA

Department of Pathology, Cambridge University, Cambridge, UK

University Department of Pathology, Western Infirmary, Glasgow, UK

Department of Health Studies, The University of Chicago, Chicago, IL, USA

Department of Pathology, University of Chicago, Chicago, IL, USA

Nuffield Department of Pathology, Oxford University, Oxford, UK

Department of Immunology, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK

Albert Einstein College of Medicine, Bronx, NY, USA

10  Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute & State University, Blacksburg, VA, USA

11  Department of Pathology, Dartmouth University School of Medicine, Hanover, NH, USA

12  Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

13  Department Pediatrics (Infectious Diseases); Committees on Molecular Medicine, Genetics, and The College, University of Chicago, Chicago, IL, USA

author email corresponding author email

Journal of Neuroinflammation 2008, 5:48doi:10.1186/1742-2094-5-48

Published: 23 October 2008

Additional files


Additional file 1:

Balance and Agility of an uninfected mouse and a chronically infected mouse. Mouse number 20 is uninfected while mouse number 5 is chronically infected with T. gondii.

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