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Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

Edward L Tobinick* and Hyman Gross

Journal of Neuroinflammation 2008, 5:2 doi:10.1186/1742-2094-5-2

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TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

Karim Belarbi, Timothy Jopson, David Tweedie, Carla Arellano, Weiming Luo, Nigel H Greig, Susanna Rosi Journal of Neuroinflammation 2012, 9:23 (25 January 2012)

Research article   Open Access

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease

Hong Jiang, Harald Hampel, David Prvulovic, Anders Wallin, Kaj Blennow, Rena Li, Yong Shen Molecular Neurodegeneration 2011, 6:69 (6 October 2011)

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Alzheimer's disease: new diagnostic and therapeutic tools

Marco Racchi, Daniela Uberti, Stefano Govoni, Maurizio Memo, Cristina Lanni, Sonya Vasto, Giuseppina Candore, Calogero Caruso, Loriana Romeo, Giovanni Scapagnini Immunity & Ageing 2008, 5:7 (13 August 2008)

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Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease

Edward L Tobinick, Hyman Gross BMC Neurology 2008, 8:27 (21 July 2008)

Two case reports and further data from a phase II clinical trial support the use of peri-spinal administration of the TNF-alpha inhibitor etanercept to improve verbal abilities in patients with Alzheimer’s disease.