Caffeine blocks high cholesterol diet-induced extravasation of fibrinogen. (A) Cholesterol-enriched diet increased extravasation of fibrinogen in olfactory bulb and this effect was blocked by caffeine at the dose of 3 mg/day. Caffeine alone had no effect on extravasation of fibrinogen in normal rabbit brain. Representative images taken from 2 rabbits in each group with 6 sections from each animal are shown. Bar = 50 μm. (B) Cholesterol-enriched diet significantly increased accumulation of fibrinogen in olfactory bulb and this effect was blocked by caffeine at the dose of 3 mg/day. (C) Neither cholesterol-enriched diet nor caffeine changed significantly plasma levels of fibrinogen. n = 4, *p < 0.05.
Chen et al. Journal of Neuroinflammation 2008 5:12 doi:10.1186/1742-2094-5-12