|
Dosage range of Stx2 and clinical findings |
|||
| Dose (μg/kg) |
neurological symptoms (%) |
Diarrhea/occult blood |
Body weight loss (%) |
|
|
|||
| 0.1 |
1a /5 (20) |
-~+/-~+ |
8.0~38.8 |
| 0.25 |
0/4 (0) |
+/+ |
13.2~25.6 |
| 0.5 |
0/4 (0) |
+/+ |
22.0~36.7 |
| 1.0 |
2/4 (50) |
+/+ |
26.7 |
| 2.0 |
5/6 (83.3) |
+/+ |
-b |
| 4.0 |
5/6 (83.3) |
+/+ |
-b |
|
aTransient gait disturbance was observed on the 4th to 6th day after administration of Stx2. bnot measured. | |||
Takahashi et al. Journal of Neuroinflammation 2008 5:11 doi:10.1186/1742-2094-5-11 |
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