Immunohistochemical staining of human brain tissue using a PGRN-specific polyclonal antibody. In a neurologically normal individual, PGRN immunoreactivity is present in hippocampal pyramidal neurons, but particularly high in CA1 (A), dentate fascia (B) and endplate/CA4 (C). In AD, neurons and activated microglia (arrows) in the endplate are labeled (D), along with PGRN immunoreactivity associated with dystrophic neurites in senile plaques (inset).
Ahmed et al. Journal of Neuroinflammation 2007 4:7 doi:10.1186/1742-2094-4-7