|
Summary of changes in gene expression in neurotrophins, growth factors, related receptors and structural proteins |
||||
| NEUROTROPHINS AND RECEPTORS |
Th1 |
M/M |
Th2 |
|
|
|
||||
| M55293 |
trkB |
-3.05* |
-2.7* |
|
| E03082 |
NT3 |
-4.15*** |
-2.71*** |
-4.73**** |
| AI030286 |
brain derived neurotrophic factor |
-4.19* |
||
| AA944973 |
NGFR p75 precursor |
-4.26** |
||
| S62933 |
trkC, alternatively spliced |
-12.13*** |
-7.01*** |
|
| AF023087 |
NGF-inducible IA |
2.30*** |
2.25* |
|
| X67108 |
brain derived neurotrophic factor |
2.11* |
||
| M86742 |
pre-pro NT4 protein |
-2.62** |
||
| Y07559 |
NT 4/5 |
-2.63** |
||
| GROWTH/MATURATION FACTORS AND RECEPTORS |
||||
| AI070577 |
insulin-like growth factor receptor 5 |
3.66** |
||
| Z14120 |
platelet-derived growth factor alpha (PDGF) |
2.99**** |
3.20*** |
2.23*** |
| M32167 |
vascular endothelial growth factor (VEGF) |
2.39* |
3.13** |
|
| D79215 |
fibroblast growth factor 10 |
2.17* |
2.59*** |
2.44* |
| M81183 |
insulin-like growth factor 1 (IGF-1) |
-2.02** |
||
| E0178 |
TGF-alpha |
-2.09** |
||
| M90660 |
insulin receptor-related receptor alpha |
-2.88** |
||
| X12748 |
epidermal growth factor precursor |
-3.48**** |
-2.53*** |
|
| U37101 |
granulocyte colony stimulating factor 3 (GCSF) |
3.24**** |
||
| D10106 |
prepropeptide PDGF A chain |
2.73*** |
2.31*** |
|
| D64085 |
fibroblast growth factor 5 |
2.18* |
||
| M18416 |
early growth response 1 |
2.03* |
||
| X07285 |
basic fibroblast growth factor |
-2.06* |
||
| U66470 |
cell growth regulatory with EF-hand domain |
-2.07* |
||
| AA818970 |
endothelin receptor type B |
2.70**** |
||
| AB008908 |
fibroblast growth factor 14 |
2.64* |
||
| AF014827 |
c-fos induced growth factor (VEGF D) |
2.24** |
||
| S54008 |
fibroblast growth factor receptor 1 |
2.01*** |
||
| U02320 |
neuregulin 1 |
-2.17** |
||
| AA875664 |
GCSF signaling molecule, mitochondria-associated |
-2.24**** |
||
| M17960 |
insulin-like growth factor II (somatomedin A) |
-2.95** |
||
| AI137657 |
platelet-derived growth factor receptor alpha |
-3.04* |
||
| HORMONES, RECEPTORS AND RELATED MOLECULES |
||||
| U94321 |
growth hormone secretagogue receptor |
3.09* |
3.13*** |
|
| M54987 |
corticotropin releasing hormone |
2.17* |
2.40* |
|
| U55836 |
parathyroid hormone receptor |
-2.39** |
||
| U25803 |
luteinizing hormone, beta subunit |
-2.57*** |
-2.14** |
-2.18* |
| M34083 |
prolactin receptor |
-2.86*** |
-2.69*** |
|
| M63296 |
luteinizing hormone receptor |
-2.92* |
||
| AA799498 |
natriuretic peptide precursor |
-3.09** |
||
| M27408 |
follicle stimuating hormone beta |
-3.21* |
-3.30* |
|
| Z33403 |
luteinizing hormone receptor |
-3.77** |
-2.80* |
|
| Z83757 |
growth hormone receptor |
-4.06* |
-3.81* |
-4.58* |
| Al235978 |
aldosterone receptor |
-6.13 |
||
| S49003 |
short isoform growth hormone receptor |
2.78* |
||
| U25802 |
luteinizing hormone, beta subunit |
-2.79*** |
||
| L40030 |
placental growth factor |
-3.33** |
||
| X01454 |
thyroid stimulating hormone, beta subunit |
-3.55*** |
||
| U41183 |
growth hormone releasing hormone |
-5.09* |
||
| M19304 |
prolactin receptor |
-5.81** |
||
| AA893618 |
glucocorticoid receptor |
-2.64* |
||
| U92469 |
gonadotropin-releasing hormone receptor |
-6.06** |
||
| AA946542 |
prolactin-like protein D |
-6.09* |
||
| Al180410 |
prolactin-like protein C |
-6.70*** |
||
| CELL ADHESION AND EXTRACELLULAR MATRIX MOLECULES |
||||
| S61868 |
syndecan 4 |
2.8* |
3.5** |
|
| AA818894 |
proteoglycan core peptide |
2.2* |
||
| U56859 |
perlecan |
-3.29* |
||
| S61868 |
syndecan 4 |
2.9* |
||
| U16845 |
neurotrimin |
2.76* |
2.68* |
|
| U09401 |
tenascin c |
3.92** |
||
| U15550 |
tenascin c |
2.3* |
||
| Al071104 |
glypican 3 |
2.04** |
||
| MI5797 |
nidogen (entactin) |
-2.02* |
||
| D50568 |
proteoglycan, bone marrow |
-2.12* |
||
| AJ011811 |
claudin 7 |
-2.12* |
||
| U35371 |
BIG-2 |
-2.47** |
||
| X63143 |
syndecan 3 (neuroglycan) |
-2.44** |
-2.35** |
|
| AA8000059 |
syndecan 4 |
-2.9** |
||
| Al639167 |
biglycan (weakly similar to bone/cartilage p.g.) |
-3.57** |
||
| CONNEXINS |
||||
| M76532 |
connexin 37 (CXN-37) |
2.76** |
||
| M59936 |
connexin-31 (CXN-31) |
2.03** |
||
| AF022136 |
connexin 40 (CXN-40) |
-2.82* |
||
| NEURONAL RELATED PROTEINS |
||||
| M74223 |
VGF nerve growth factor inducible |
3.04*** |
3.79*** |
2.25*** |
| AF031430 |
syntaxin 7 |
2.09*** |
||
| AF056704 |
synapsin 3 |
-2.18* |
-4.27*** |
|
| S96418 |
activin receptor IIA |
-3.41* |
||
| U69702 |
activin receptor-like kinase 7 |
-3.62** |
||
| AA818677 |
neurofilament, heavy polypeptide |
-4.16* |
||
| Y16563 |
bassoon |
-4.88* |
||
| X17682 |
MAP 2 |
3.33** |
||
| U22952 |
neuroligin |
2.49*** |
||
| X66840 |
MAP 1A |
-2.07* |
||
| X06655 |
synaptophysin |
-2.13*** |
||
| X06655 |
synaptophysin 2 |
-2.19**** |
||
| M64488 |
synaptotagmin |
-2.20**** |
||
| U71924 |
synaptotagmin XII |
-4.56* |
||
| AF041246 |
hypocretin (orexin) |
-5.88* |
-3.87*** |
|
| L20820 |
syntaxin 3 |
-2.43*** |
||
| X95286 |
semaphorin 3a |
-2.94*** |
||
| RETINAL PROTEINS |
||||
| X52376 |
rds/peripherin |
2.09*** |
2.15*** |
|
| Z46957 |
rhodopsin |
-4.64*** |
-5.14** |
|
| CANCER RELATED PROTEINS |
||||
| AF036760 |
breast cancer 1 |
-2.28* |
-2.52* |
-2.05* |
| U68725 |
deleted in colorectal cancer (rat homolog) |
-4.05** |
||
| U32081 |
deleted in malignant brain tumors 1 |
-6.02*** |
||
| M32475 |
carcinoembryonic antigen |
-4.58* |
||
| BONE-RELATED PROTEINS |
||||
| Y07704 |
Best 5 protein |
39.49**** |
7.02** |
|
| Y07704 |
Best 5 protein |
31.46*** |
7.41* |
|
| AA892798 |
USAG (uterine-sensitized associated gene 1) |
-2.10* |
||
|
Values represent averages of fold changes from three separate experiments for each cytokine mixture compared to control. **** p < 0.01; *** p < 0.05; ** p < 0.10; * p < 0.20 | ||||
Lisak et al. Journal of Neuroinflammation 2007 4:30 doi:10.1186/1742-2094-4-30 |
||||