Table 4 |
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|
Associations of AD with HLA-B7 and HLA-Cw*0702 by APOE4 status |
||||
| Allele |
APOE4 status |
Proportions of alleles |
Adjusted† odds ratios of AD (95% CI, p) |
|
|
|
||||
| Controls |
AD |
|||
|
|
||||
| HLA-B7 |
Positive |
14/110 |
42/246 |
1.7 (0.8–3.55, 0.19) |
| Negative |
28/288 |
30/146 |
2.8 (1.5–5.2, 0.002) |
|
| All |
42/398 |
72/392 |
2.3 (1.4–3.7, 0.001) |
|
|
|
||||
| HLA-Cw*0702 |
Positive |
14/110 |
45/244 |
1.7 (0.8–3.6, 0.15) |
| Negative |
34/288 |
31/146 |
2.2 (1.2–4.0, 0.01) |
|
| All |
48/398 |
76/390 |
2.0 (1.3–3.1, 0.003) |
|
|
AD = Alzheimer's disease, APOE4 = the ε4 allele of apolipoprotein E, CI = confidence interval †for age, gender and APOE4 | ||||
Lehmann et al. Journal of Neuroinflammation 2006 3:33 doi:10.1186/1742-2094-3-33 |
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