|
Associations of AD with HLA-B7 and HLA-Cw*0702 by study |
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| Allele |
Study |
Proportions of alleles |
Adjusted‡ odds ratios of AD (95% CI, p) |
|
|
|
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| Controls |
AD |
|||
|
|
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| HLA-B7 |
Previous† |
10/112 |
26/110 |
3.1 (1.2–8.0, 0.02) |
| Replication |
32/286 |
46/282 |
1.9 (1.03–3.4, 0.04) |
|
| All |
42/398 |
72/392 |
2.3 (1.4–3.7, 0.001) |
|
|
|
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| HLA-Cw*0702 |
Previous† |
14/112 |
28/108 |
2.7 (1.1–6.3, 0.03) |
| Replication |
34/286 |
48/282 |
1.7 (0.95–2.9, 0.08) |
|
| All |
48/398 |
76/390 |
2.0 (1.3–3.1, 0.003) |
|
|
†results included in our 2001 report [9] AD = Alzheimer's disease, CI = confidence interval ‡for age, gender and the ε4 allele of apolipoprotein E | ||||
Lehmann et al. Journal of Neuroinflammation 2006 3:33 doi:10.1186/1742-2094-3-33 |
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