Table 2

HLA-C alleles in controls and in Alzheimer's disease

Allele
Homozygotes/heterozygotes/negatives (n)
Allelic frequency (%)
Unadjusted allelic odds ratio of AD (95% CI, p)
Hardy-Weinberg equilibrium (p)



Controls
AD
Controls
AD

Controls
AD

HLA-Cw1
0/9/190
1/14/180
2.3
4.1
1.85 (0.8–4.2, 0.2)
0.7
0.2
HLA-Cw2
0/15/184
0/16/179
3.8
4.1
1.1 (0.5–2.2, 0.9)
0.6
0.55
HLA-Cw4
1/36/162
1/34/160
9.5
9.2
1.0 (0.6–1.6, 0.9)
0.5
0.6
HLA-Cw5
1/36/162
1/40/154
9.5
10.8
1.1 (0.7–1.8, 0.6)
0.5
0.35
HLA-Cw6
4/31/164
2/31/162
9.8
9.0
0.9 (0.6–1.5, 0.7)
0.09
0.7
HLA-Cw*0701
6/62/131
7/56/132
18.6
17.9
1.0 (0.7–1.4, 0.85)
0.7
0.7
HLA-Cw*0702
1/46/152
9/58/128
12.1
19.5
1.8 (1.2–2.6, 0.0045)
0.2
0.5
HLA-Cw*0704
0/8/191
0/3/192
2.0
0.8
0.4 (0.1–1.4, 0.2)
0.8
0.9
HLA-Cw8
0/17/182
1/11/183
4.3
3.3
0.8 (0.4–1.6, 0.6)
0.5
0.08
HLA-Cw9
0/29/170
0/25/170
7.3
6.4
0.9 (0.5–1.5, 0.7)
0.3
0.3
HLA-Cw10
1/37/161
2/24/169
9.8
7.2
0.7 (0.4–1.2, 0.2)
0.5
0.3
HLA-Cw12
1/11/187
0/8/187
3.3
2.1
0.6 (0.25–1.5, 0.4)
0.08
0.8
HLA-Cw15
0/13/186
0/2/193
3.3
0.5
0.15 (0.03–0.7, 0.007)
0.6
0.9
HLA-Cw16
0/13/186
1/13/181
3.3
3.8
1.2 (0.6–2.5, 0.7)
0.6
0.2

AD = Alzheimer's disease, CI = confidence interval uncorrected

Lehmann et al. Journal of Neuroinflammation 2006 3:33   doi:10.1186/1742-2094-3-33