|
HLA-B alleles in controls and in Alzheimer's disease |
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| Allele |
Homozygotes/heterozygotes/negatives (n) |
Allelic frequency (%) |
Unadjusted allelic odds ratio of AD (95% CI, p†) |
Hardy-Weinberg equilibrium (p†) |
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|
|
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| Controls |
AD |
Controls |
AD |
Controls |
AD |
||
|
|
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| HLA-B7 |
0/42/157 |
7/58/131 |
10.6 |
18.4 |
1.9 (1.3–2.9, 0.002) |
0.1 |
0.85 |
| HLA-B8 |
5/49/145 |
6/45/145 |
14.8 |
14.5 |
1.0 (0.7–1.45, 0.9) |
0.7 |
0.3 |
| HLA-B18 |
1/16/182 |
1/11/184 |
4.5 |
3.3 |
0.7 (0.35–1.5, 0.5) |
0.3 |
0.08 |
| HLA-B27 |
0/11/188 |
0/18/178 |
2.8 |
4.6 |
1.7 (0.8–3.6, 0.2) |
0.7 |
0.5 |
| HLA-B35 |
0/22/177 |
1/25/170 |
5.5 |
6.9 |
1.3 (0.7–2.3, 0.5) |
0.4 |
0.9 |
| HLA-B39 |
1/9/189 |
0/7/189 |
2.8 |
1.8 |
0.6 (0.25–1.7, 0.5) |
0.025 |
0.8 |
| HLA-B44 |
3/56/140 |
7/48/141 |
15.6 |
15.8 |
1.0 (0.7–1.5, 1.0) |
0.3 |
0.3 |
| HLA-B51 |
0/20/179 |
1/8/187 |
5.0 |
2.6 |
0.5 (0.2–1.1, 0.09) |
0.5 |
0.01 |
| HLA-B57 |
0/19/180 |
1/19/176 |
4.8 |
5.4 |
1.1 (0.6–2.1, 0.75) |
0.5 |
0.5 |
| HLA-B60 |
1/31/167 |
0/19/177 |
8.3 |
4.8 |
0.6 (0.3–1.0, 0.06) |
0.7 |
0.5 |
| HLA-B62 |
1/31/167 |
0/23/173 |
8.3 |
5.9 |
0.7 (0.4–1.2, 0.2) |
0.7 |
0.4 |
| HLA-B65 |
0/13/186 |
1/4/191 |
3.3 |
1.5 |
0.5 (0.2–1.2, 0.2) |
0.6 |
0.0001 |
|
AD = Alzheimer's disease, CI = confidence interval †uncorrected | |||||||
Lehmann et al. Journal of Neuroinflammation 2006 3:33 doi:10.1186/1742-2094-3-33 |
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