Figure 3.

Macrophages and microglia were reduced by CHEC-9 treatment of EAE. Graph (left panel): The density of ED-1+ cells in the spinal cord was reduced over 60% following peptide treatment (p < 1 × 10^-3). Although the immunostained cells tended to accumulate at or near the surface of both groups, fewer cells, occupying a smaller area within the cord were found CHEC-9 treated rats (B) compared to vehicle treated rats (C). The majority of intraspinal ED-1 immunoreactive cells were activated microglia (arrows).