Table 1 |
||||
|
Kinetic Parameters at Different Inhibitor Concentrations |
||||
| Group I sPLA2 |
||||
| [CHEC-9] nM |
0.0 |
0.1 |
1.0 |
10.0 |
|
|
||||
| Vmax nM/min/ng |
21.67 |
11.54 |
5.56 |
4.04 |
| Km μM |
18.80 |
10.77 |
3.40 |
2.26 |
| r2 |
0.896 |
0.942 |
0.851 |
0.752 |
|
|
||||
| Ki = 4.02 ± 1.56 nM |
||||
| Human Plasma sPLA2 |
||||
|
|
||||
| [CHEC-9] nM |
0.0 |
10.0 |
50.0 |
|
|
|
||||
| Vmax μM/min/ml |
2.07 |
1.42 |
0.973 |
|
| Km |
66.52 |
40.79 |
24.06 |
|
| r2 |
.981 |
.957 |
.970 |
|
|
Ki = 62.01 ± 13.2 nM r2 = fit to Michaelis-Menton Equation | ||||
Cunningham et al. Journal of Neuroinflammation 2006 3:25 doi:10.1186/1742-2094-3-25 |
||||
