|
Infarct volume, infarct area and neurological score in untreated (vehicle) and 5-LOX inhibitor-treated rats at 24 h reperfusion after 20 min MCAO. |
||||
| A.Infarct volume and infarct area |
||||
| Group |
N |
Infarct volume (mm3) |
Infarct area (%) |
|
|
|
||||
| Vehicle |
7 |
522.5 ± 11.2 |
41.3 ± 10.5 |
|
| Caffeic acid |
7 |
229.5 ± 18.5* |
12.8 ± 1.9* |
|
| AA-861 |
7 |
210.4 ± 20.5* |
11.3 ± 2.9* |
|
| BW-B 70C |
7 |
205.2 ± 8.9* |
11.8 ± 2.1* |
|
|
|
||||
| B.Neurological Score |
Number of animals = 7 |
|||
|
|
||||
| Vehicle |
Caffeic acid |
AA-861 |
BW-B 70C |
|
|
|
||||
| Frequencies |
||||
|
|
||||
| 0 |
0 |
0 |
0 |
0 |
| 1 |
0 |
4 |
4 |
5 |
| 2 |
0 |
3 |
2 |
2 |
| 3 |
6 |
0 |
1 |
0 |
| 4 |
1 |
0 |
0 |
0 |
|
|
||||
| Median |
3 |
1 |
1 |
1 |
|
Infarct volume and infarct area (A) and neurological deficit score (B) were measured at 24 h of reperfusion after 20 min MCAO. Animals were treated either with 5-LOX inhibitors dissolved in DMSO alone (vehicle) at reperfusion as described in Methods. Data in Table B represent number of animals showing corresponding neurological score (ranging from 0 to 4 as detailed in Methods). Data are expressed as mean ± SD for infarct area and infarct volume and as range and median for neurological deficit score. *p < 0.001 vs. vehicle. | ||||
Jatana et al. Journal of Neuroinflammation 2006 3:12 doi:10.1186/1742-2094-3-12 |
||||