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Effect of different doses of nimesulide on neurological deficits and functional outcome (evaluated using the rotarod test) following permanent middle cerebral artery occlusion in the rat. |
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| Treatment |
Neurological Score |
Rotarod performance (% of presurgery levels) |
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|
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| Sham-operated control (n = 8) |
0 |
128 ± 21 |
| Repeated doses |
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| Vehicle (n = 9) |
3 (3–5) |
49 ± 18 |
| Nimesulide 3 mg/kg (n = 7) |
3 (2–4) |
64 ± 13 |
| Nimesulide 6 mg/kg (n = 8) |
2 (1–5) * |
89 ± 20 ** |
| Nimesulide 12 mg/kg (n = 9) |
2 (1–4) ** |
84 ± 14 ** |
| Single dose |
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| Vehicle, single dose (n = 7) |
3 (3–5) |
43 ± 21 |
| Nimesulide 12 mg/kg, single dose (n = 8) |
3.5 (2–5) |
52 ± 19 |
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Values show the median and range (neurological score) and means ± S.D. (rotarod performance). For the analysis of neurological score data, the Kruskal-Wallis nonparametric ANOVA followed by Dunn test (multiple comparison) or Mann-Whitney test for analysis of individual differences were used. For the statistical analysis of rotarod performance results, ANOVA followed by Student-Newman-Keuls post-hoc test was employed. * P < 0.05 and ** P < 0.01 compared to vehicle. | ||
Candelario-Jalil et al. Journal of Neuroinflammation 2005 2:3 doi:10.1186/1742-2094-2-3 |
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