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Effect of different doses of the cyclooxygenase-2 inhibitor nimesulide on total, cortical and subcortical infarct volumes in a rat model of permanent focal cerebral ischemia. |
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| Treatment |
Total infarct volume (%) |
Cortical infarct volume (%) |
Subcortical infarct volume (%) |
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| Repeated doses |
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| Vehicle (n = 9) |
56.1 ± 11.4 |
41.6 ± 10.3 |
12.6 ± 4.5 |
| Nimesulide 3 mg/kg (n = 7) |
54.9 ± 14.9 |
38.1 ± 17.2 |
14.3 ± 2.4 |
| Nimesulide 6 mg/kg (n = 8) |
41.4 ± 12.3 |
31.8 ± 9.3 |
9.7 ± 3.5 |
| Nimesulide 12 mg/kg (n = 9) |
34.1 ± 13.8 ** |
24.6 ± 11.2 ** |
7.1 ± 3.9 * |
| Single dose |
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| Vehicle, single dose (n = 7) |
55.2 ± 15.5 |
43.9 ± 10.9 |
13.2 ± 4.2 |
| Nimesulide 12 mg/kg, single dose (n = 8) |
49.5 ± 11.7 |
39.4 ± 11.8 |
9.1 ± 3.1& |
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Data are mean ± S.D. * P < 0.05 and ** P < 0.01 compared to vehicle. One-way ANOVA followed by Student-Newman-Keuls post-hoc test. &P < 0.05 compared to vehicle single dose (Student's t-test). | |||
Candelario-Jalil et al. Journal of Neuroinflammation 2005 2:3 doi:10.1186/1742-2094-2-3 |
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