Table 1

Different stages defined in amyotrophic lateral sclerosis
Stage Age Phenotype
Pre-symptomatic 30 days postnatal No signs of motor deficit
Onset 70 days postnatal Initial signs of motor deficit (grip strength)
Mid-symptomatic 130 days postnatal Weakness in hind-limb and tremor when suspended by the tail
End 150 to 175 days postnatal Full paralysis of lower limbs and loss of righting reflex

Lee et al.

Lee et al. Journal of Neuroinflammation 2013 10:119   doi:10.1186/1742-2094-10-119

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