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Ginkgolide B-treated SH-SY5Y cells are resistant to PAF or arachidonic acid: The survival of untreated cells, and cells treated with 1 μM ginkgolide B, subsequently incubated with different neurotoxins at the concentrations shown. Values shown represent the percentage survival of treated cells compared to untreated cells. Each value is the mean ± SD from triplicate experiments repeated three times (9 observations). |
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| conc |
untreated cells |
ginkgolide B-treated cells |
|
|
|
|||
| medium |
100 ± 3 |
98 ± 5 |
|
| arachidonic acid (μM) |
50 |
14 ± 2 |
46 ± 3** |
| 25 |
25 ± 5 |
72 ± 6** |
|
| 12.5 |
57 ± 3 |
93 ± 4** |
|
| hydrogen peroxide (μM) |
20 |
3 ± 1 |
3 ± 2 |
| 10 |
7 ± 2 |
8 ± 2 |
|
| 5 |
46 ± 4 |
48 ± 6 |
|
| PAF (μM) |
40 |
18 ± 1 |
75 ± 7** |
| 20 |
37 ± 2 |
97 ± 3** |
|
| 10 |
62 ± 3 |
100 ± 2** |
|
| staurosporine (ng/ml) |
20 |
40 ± 3 |
38 ± 3 |
| 4 |
72 ± 4 |
69 ± 2 |
|
| 0.8 |
93 ± 3 |
95 ± 3 |
|
|
** = Cell survival significantly greater (p < 0.05) than untreated cells incubated with neurotoxin. | |||
Bate et al. Journal of Neuroinflammation 2004 1:4 doi:10.1186/1742-2094-1-4 |
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