Table 1

Ginkgolide-treated SH-SY5Y cells are resistant to PrP peptides/amyloid-β1-42: The survival of SHSY-5Y cells in control medium, medium containing 1 μM ginkgolides A, 1 μM ginkgolide B, 25 μM myricetin or 25 μM quercetin for 3 hours and subsequently incubated for 24 hours with 5 μM sPrP106, 10 μM HuPrP82-146 or 10 μM amyloid-β1-42. Values shown represent the percentage survival of cells compared to untreated cells. Each value is the mean ± SD from triplicate experiments repeated four times (12 observations).

untreated
 sPrP106
 HuPrP82-146
 amyloid-β1-42
control medium
 100 ± 3
 69 ± 4
 64 ± 6
 48 ± 10
ginkgolide A
 101 ± 5
 99 ± 3**
 101 ± 2**
 99 ± 4**
ginkgolide B
 99 ± 3
 99 ± 5**
 98 ± 3**
 96 ± 3**
myricetin
 101 ± 7
 67 ± 3
 65 ± 3
 46 ± 5
quercetin
 100 ± 4
 66 ± 4
 66 ± 5
 44 ± 5

** = Cell survival significantly greater (p < 0.05) than cells incubated with peptides in the absence of drugs.

Bate et al. Journal of Neuroinflammation 2004 1:4   doi:10.1186/1742-2094-1-4