Passive immunization with anti-Aβ antibodies decreases total and parenchymal amyloid loads while increasing vascular amyloid in frontal cortex and hippocampus of APP-transgenic mice. Panel A shows total amyloid load measured with Congo red, vascular amyloid load and parenchymal amyloid load from APP-transgenic mice administered control IgG (C) or anti-Aβ IgG (Aβ) for a period of 5 months. Panels B-D show total amyloid load (Panel B), vascular amyloid load (Panel C) and parenchymal amyloid load (Panel D) from APP-transgenic mice administered control IgG for 3 months (Cont IgG) or anti-Aβ IgG for a period of 1, 2, or 3 months (Anti-Aβ IgG). For all panels, the solid bar and solid line represent values from the frontal cortex, while the open bar and dashed line represent values from the hippocampus. ** p < 0.01.
Wilcock et al. Journal of Neuroinflammation 2004 1:24 doi:10.1186/1742-2094-1-24