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Effects of indomethacin plus vitamin E on total brain cortex levels of PGE2, TxB2 and IL-1β in Tg2576 mice. Mice were treated starting at 8-months of age until they were 15-month-old (n = 10 animals per group). |
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| Placebo |
Indomethacin Vitamin E |
P |
|
|
|
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| PGE2 (pg/mg tissue) |
92 ± 8 |
39 ± 5* |
<0.01 |
| TxB2 (pg/mg tissue) |
148 ± 10 |
15 ± 4* |
<0.001 |
| IL-1β (pg/mg protein) |
75 ± 12 |
33 ± 8* |
<0.01 |
|
Values are expressed as means ± S.E.M. | |||
Yao et al. Journal of Neuroinflammation 2004 1:21 doi:10.1186/1742-2094-1-21 |
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